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Contractile Reserve in Dyssynchrony: A Novel Principle to Identify Candidates for Cardiac Resynchronization Therapy

NCT02525185 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 200

Last updated 2023-11-01

No results posted yet for this study

Summary

Cardiac resynchronisation therapy (CRT) has been documented to be a powerful treatment in patients with severe congestive heart failure. However, 30-40% of patients receiving a CRT are non-responders. In this study the investigators will use a previously validated method to estimate myocardial segment work non-invasively by speckle-tracking echocardiography and blood pressure. Furthermore, cardiac magnetic resonance imaging (CMR) with late gadolinium enhancement (LGE) will be performed in feasible subjects. The main purpose of the study is to determine if myocardial work by echocardiography in combination with viability assessment by LGE-CMR can predict response to CRT.

Conditions

Interventions

OTHER

Diagnostic interventions; PET, MRI, cardiac ultrasound.

Sponsors & Collaborators

  • Karolinska University Hospital

    collaborator OTHER

  • Universitaire Ziekenhuizen KU Leuven

    collaborator OTHER

  • Rennes University Hospital

    collaborator OTHER

  • Onze Lieve Vrouwziekenhuis Aalst

    collaborator OTHER

  • Oslo University Hospital

    lead OTHER

Principal Investigators

  • Otto A Smiseth, MD PhD · Oslo University Hospital

  • Jens-Uwe Voigt, MD PhD · Universitaire Ziekenhuizen KU Leuven

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2015-09-30
Primary Completion
2018-07-01
Completion
2023-08-31

Countries

  • Belgium
  • Norway

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02525185 on ClinicalTrials.gov