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Does Sweet Taste Potentiate Nicotine Cue Reactivity?

NCT02499757 · Status: COMPLETED · Phase: PHASE1 · Type: INTERVENTIONAL · Enrollment: 15

Last updated 2020-03-09

No results posted yet for this study

Summary

The investigators' aim is to test the prediction that sweet taste perception enhances the ability of nicotine to induce neural plastic changes in brain reward circuits to increase the saliency, liking and brain reactivity to the sight and vaporized flavor of electronic cigarettes (e-cigarettes).

Conditions

  • Healthy

Interventions

DEVICE

flavor and sweetener

maltol added as sweetener to e-cigarette with flavor

DEVICE

flavor and nicotine

12 mg of nicotine added to e-cigarette with flavor

DEVICE

flavor, nicotine and sweetener

12 mg nicotine and maltol (sweetener) added to e-cigarette with flavor

DEVICE

flavor

flavored e-cigarette stand alone without added nicotine and maltol (sweetener)

Sponsors & Collaborators

  • National Institute on Drug Abuse (NIDA)

    collaborator NIH

  • Yale University

    lead OTHER

Principal Investigators

  • Dana M Small · The John B. Pierce Laboratory

Study Design

Allocation
NON_RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
DOUBLE
Model
FACTORIAL

Eligibility

Min Age
18 Years
Max Age
45 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2015-05-31
Primary Completion
2015-11-30
Completion
2015-11-30

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02499757 on ClinicalTrials.gov