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Ketones Influence on Glucose Metabolism in Brain. A Human Positron Emission Tomography (PET) Study

NCT02357550 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 9

Last updated 2016-01-18

No results posted yet for this study

Summary

This project tend to investigate the affection of ketone bodies on brain metabolism. This will be done by measuring human cerebral uptake of energy substrates, together with functional parameters, using PET imaging and appropriate radiotracers under hyperketonemia in healthy subjects by ketone infusion.

Hypotheses

1. Increased levels of ketone bodies in healthy subjects leads to decreased glucose uptake by brain cells contributing to hyperglycaemia.
2. Increased levels of ketone bodies in healthy subjects leads to increased cerebral blood flow.
3. Altered oxygen consumption during hyperketonemia in healthy subjects.

Conditions

  • Ketone Body Metabolism
  • Brain Metabolism

Interventions

DRUG

ketone

3-OHB is infused intravenously.

DRUG

placebo

Saline infusion.

Sponsors & Collaborators

  • University of Aarhus

    lead OTHER

Principal Investigators

  • Mads Svart, MD · Aarhus University / Aarhus University Hospital

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
SINGLE
Model
CROSSOVER

Eligibility

Min Age
50 Years
Max Age
70 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2015-03-31
Primary Completion
2016-01-31
Completion
2016-01-31

Countries

  • Denmark

Study Locations

More Related Trials

Entities

Drugs

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02357550 on ClinicalTrials.gov