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Supplementing Neuro-Energy to Aid Cognition

NCT06767124 · Status: NOT_YET_RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 17

Last updated 2025-10-14

No results posted yet for this study

Summary

It is projected that by 2030, one in every five Americans will be of retirement age, and this demographic shift is expected to result in more people suffering from dementia. A key feature of the brain is its need for a constant supply of glucose and oxygen to meet the high energy costs of mental activity. This study aims to develop clinically practical, noninvasive imaging methods based on combined positron emission tomography and magnetic resonance imaging to assess brain energy in order to better understand how this critical component of brain health is impacted by aging.

Conditions

  • Alzheimer Disease and Related Dementias (ADRD)

Interventions

DIETARY_SUPPLEMENT

Ketogenic Supplement

Commercially available ketone ester drink

OTHER

Placebo Drink

Placebo drink containing sunflower oil.

Sponsors & Collaborators

  • National Institute of Neurological Disorders and Stroke (NINDS)

    collaborator NIH

  • University of Western Ontario, Canada

    collaborator OTHER

  • University of Pennsylvania

    lead OTHER

Principal Investigators

  • Keith St Lawrence, PhD · Lawson Research Institute

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Model
CROSSOVER

Eligibility

Min Age
21 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2026-05-01
Primary Completion
2028-02-29
Completion
2028-03-31

Countries

  • Canada

Study Locations

More Related Trials

Entities

Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06767124 on ClinicalTrials.gov