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PET Imaging in Chronic Traumatic Encephalopathy

NCT02211820 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 6

Last updated 2018-07-05

No results posted yet for this study

Summary

Background:

\- Chronic traumatic encephalopathy (CTE) is a brain disease caused in part by head injury. The brain changes from CTE can only be seen at autopsy. Researchers want to test a new brain scan to help diagnose CTE in living patients.

Objective:

\- To determine if a new type of brain scan can detect changes that occur in chronic traumatic encephalopathy.

Eligibility:

\- Adults age 18 60 with previous head injury or participation in certain sports.

Design:

* Participants will be screened with:
* Physical exam
* Blood and urine tests
* Tests of thinking, mood, and memory
* 30-minute magnetic resonance imaging (MRI) brain scan. A magnetic field and radio waves take pictures of the brain. Participants will lie on a table that slides into a metal cylinder. They will get earplugs for the loud knocking sounds.
* Visit 1: Participants will have a 70-minute PET scan of the brain with a small amount of a radioactive chemical. That will be injected through an intravenous tube (catheter) in each arm. A catheter will also be put into an artery at the wrist or elbow.
* Participants will lie on a bed that slides in and out of a donut-shaped scanner. A plastic mask may be molded to their face and head. Vital signs and heart activity will be checked before and during the scan.
* Blood and urine will be taken before and after the scan.
* Participants will be checked on by phone the next day.
* Visit 2: Participants will repeat Visit 1 with a different chemical and no artery catheter.
* Visit 3: Participants may have a spinal tap. Some fluid will be removed by needle between the bones in the back.

Conditions

  • Brain Disease
  • Brain Mapping

Sponsors & Collaborators

  • National Institute of Mental Health (NIMH)

    lead NIH

Principal Investigators

  • Robert B Innis, M.D. · National Institute of Mental Health (NIMH)

Eligibility

Min Age
18 Years
Max Age
60 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2014-08-01
Primary Completion
2016-06-20
Completion
2016-10-12

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02211820 on ClinicalTrials.gov