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Metabolic Abnormalities in Children With Epilepsy

NCT00001325 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 80

Last updated 2008-03-04

No results posted yet for this study

Summary

This study is designed to use positron emission tomography to measure brain energy use. Positron Emission Tomography (PET) is a technique used to investigate the functional activity of the brain. The PET technique allows doctors to study the normal processes of the brain (central nervous system) of normal individuals and patients with neurologic illnesses without physical / structural damage to the brain.

When a region of the brain is active, it uses more fuel in the form of oxygen and sugar (glucose). As the brain uses more fuel it produces more waste products, carbon dioxide and water. Blood carries fuel to the brain and waste products away from the brain. As brain activity increases blood flow to and from the area of activity increases also.

Researchers can label a sugar with a small radioactive molecule called FDG (fluorodeoxyglucose). As areas of the brain use more sugar the PET scan will detect the FDG and show the areas of the brain that are active. By using this technique researchers hope to answer the following questions;

4\. Are changes in brain energy use (metabolism) present early in the course of epilepsy

5\. Do changes in brain metabolism match the severity of patient's seizures

6\. Do changes in metabolism occur over time or in response to drug therapy

Conditions

  • Generalized Epilepsy
  • Infantile Spasms
  • Metabolic Disease
  • Partial Epilepsy
  • Seizures

Interventions

DRUG

18 FDG

Sponsors & Collaborators

  • National Institute of Neurological Disorders and Stroke (NINDS)

    lead NIH

Eligibility

Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
1992-04-30
Completion
2004-06-30

Countries

  • United States

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00001325 on ClinicalTrials.gov