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Testosterone Regulation of the Natriuretic Peptide System

NCT02269072 · Status: WITHDRAWN · Phase: NA · Type: INTERVENTIONAL

Last updated 2017-10-19

No results posted yet for this study

Summary

The proposed study is a physiologic investigation of the effects of testosterone on the natriuretic peptide system. The hypotheses of the study are that testosterone administration will decrease natriuretic peptide levels and salt excretion. The entire protocol is 8 weeks in duration.

Conditions

Interventions

DRUG

Testosterone

Testosterone cream applied daily for two weeks

DRUG

Nesiritide

Administered IV once during the study

DRUG

Leuprolide

Administered twice during the study by injection

DRUG

Anastrozole

Daily pill for 8 weeks

DRUG

Placebo

Inert cream otherwise identical to testosterone cream applied daily for two weeks

Sponsors & Collaborators

  • Massachusetts General Hospital

    lead OTHER

Principal Investigators

  • Karen K Miller, MD · Massachusetts General Hospital

Study Design

Allocation
RANDOMIZED
Purpose
OTHER
Masking
DOUBLE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Max Age
40 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2015-02-28
Primary Completion
2016-02-29
Completion
2016-02-29

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02269072 on ClinicalTrials.gov