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The Effect of High and Low Sodium Intake on Urinary Aquaporin-2 in Essential Hypertension

NCT00345124 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 50

Last updated 2011-06-28

No results posted yet for this study

Summary

The aim of the study is to test the following hypotheses:

* that the function and/or regulation of AQP2 and/or ENaC in the principal cells is abnormal in essential hypertension.
* if an abnormal function of the principal cells is present in essential hypertension, this will become more pronounced at high and low sodium intake.

Conditions

  • Essential Hypertension and Healthy Controls

Interventions

BEHAVIORAL

high sodium diet

250-350 mmol

BEHAVIORAL

Low Sodium Diet

25-35 mmol

Sponsors & Collaborators

  • Regional Hospital Holstebro

    lead OTHER

Principal Investigators

  • Erling B. Pedersen, Professor · Department of Medical Research, Holstebro Hospital, Denmark

  • Carolina C. Graffe, MD · Department of Medical Research, Holstebro Hospital, Denmark

Study Design

Allocation
RANDOMIZED
Masking
DOUBLE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Max Age
65 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2006-05-31
Primary Completion
2009-05-31
Completion
2009-08-31

Countries

  • Denmark

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00345124 on ClinicalTrials.gov