MedTrace Logo

Lysine-specific Demethylase 1 and Salt-sensitivity in Humans

NCT03029806 · Status: ACTIVE_NOT_RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 88

Last updated 2025-11-21

No results posted yet for this study

Summary

The purpose of this study is to investigate the role dietary salt plays in epigenetic regulation of blood pressure, focusing on the salt-sensitive regulatory enzyme Lysine-specific demethylase 1.

Conditions

  • Healthy Subjects

Interventions

OTHER

Aldosterone response to AngII LS

Change in aldosterone from baseline to after Ang II infusion on a LS diet

OTHER

Renal blood flow response to salt

Change in renal blood flow: High salt to low salt diet

OTHER

Vascular Stiffness

Change in vascular stiffness, baseline compared to AngII

Sponsors & Collaborators

  • Brigham and Women's Hospital

    lead OTHER

Study Design

Allocation
NON_RANDOMIZED
Purpose
OTHER
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
25 Years
Max Age
45 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2017-01-02
Primary Completion
2022-01-02
Completion
2026-06-01

Countries

  • United States

Study Locations

More Related Trials

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03029806 on ClinicalTrials.gov