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Urinary Prostaglandin as a Potential Predictive Marker for Thiazide-induced Hyponatremia

NCT05542056 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 232

Last updated 2025-07-01

No results posted yet for this study

Summary

Thiazides and thiazide-like diuretics are one of the five major classes of antihypertensive drugs. This study is to investigate whether urinary PGE2 concentration at baseline (prior to thiazide initiation) is associated with the development of TIH within the first four weeks of treatment.

Conditions

  • Thiazide-induced Hyponatremia (TIH)

Interventions

OTHER

Data and biosample collection

Collection of spot urine, blood sampling, vital parameters, body weight, medical history, patient questionnaires, drinking protocol, drug diary at at Visit 1 (before thiazide initiation), at Optional 2 hours-challenge, at Visit 2 (4 weeks after thiazide initiation), at Visit 2.1 (4 weeks after dose change), at Visit 3 (3-months after thiazide initiation)

Sponsors & Collaborators

  • University Hospital, Basel, Switzerland

    lead OTHER

Principal Investigators

  • Mirjam Christ-Crain, Prof. Dr. med. · University Hospital Basel, Endocrinology, Diabetes and Metabolism

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2022-09-26
Primary Completion
2026-07-31
Completion
2026-07-31

Countries

  • Spain
  • Switzerland

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05542056 on ClinicalTrials.gov