Study to Explore the Safety, Tolerability and Efficacy of MK-3475 in Combination With INCB024360 in Participants With Selected Cancers
NCT02178722 · Status: COMPLETED · Phase: PHASE1/PHASE2 · Type: INTERVENTIONAL · Enrollment: 444
Last updated 2022-02-14
Summary
The purpose of this study was to assess the safety, tolerability, and efficacy when combining MK-3475 and INCB024360 in participants with certain cancers. This study was conducted in 2 phases, Phase 1 and Phase 2.
Conditions
- Microsatellite-instability (MSI) High Colorectal Cancer (CRC)
- Endometrial Cancer
- Head and Neck Cancer
- Hepatocellular Carcinoma (HCC)
- Gastric Cancer
- Lung Cancer
- Lymphoma
- Renal Cell Carcinoma (RCC)
- Ovarian Cancer
- Solid Tumors
- UC (Urothelial Cancer)
- Melanoma
- Bladder Cancer
- Triple Negative Breast Cancer (TNBC)
Interventions
- DRUG
-
MK-3475
IV infusion
- DRUG
-
INCB024360
Oral daily dosing
Sponsors & Collaborators
- collaborator INDUSTRY
- lead INDUSTRY
Principal Investigators
-
Mark Jones, MD · Incyte Corporation
Study Design
- Allocation
- NON_RANDOMIZED
- Purpose
- TREATMENT
- Masking
- NONE
- Model
- PARALLEL
Eligibility
- Min Age
- 18 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2014-07-17
- Primary Completion
- 2018-11-26
- Completion
- 2020-11-06
Countries
- United States
Study Locations
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