Pharmacokinetic and Safety Study of MRX-2843 in Adults With Relapsed/Refractory Advanced and/or Metastatic Solid Tumors
NCT03510104 · Status: COMPLETED · Phase: PHASE1 · Type: INTERVENTIONAL · Enrollment: 42
Last updated 2026-01-08
Summary
This first-in-human open-label, dose escalation study is designed to evaluate the safety, tolerability, and PK of MRX-2843 in subjects with relapsed/refractory advanced and/or metastatic solid tumors.
Conditions
- Advanced Cancer
- Metastatic Cancer
- Neoplasms
- Neoplasm Metastasis
- Neoplastic Processes
- Pathologic Processes
Interventions
- DRUG
-
MRX-2843
MRX-2843 capsules
Sponsors & Collaborators
-
Meryx, Inc.
lead INDUSTRY
Principal Investigators
-
Donald Harvey · Emory University
Study Design
- Allocation
- NA
- Purpose
- TREATMENT
- Masking
- NONE
- Model
- SINGLE_GROUP
Eligibility
- Min Age
- 18 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2018-05-22
- Primary Completion
- 2025-12-31
- Completion
- 2025-12-31
- FDA Drug
- Yes
Countries
- United States
Study Locations
More Related Trials
-
A Phase I Study, Evaluating the Safety, Pharmacokinetics and Efficacy of PRJ1-3024 in Subjects With Advanced Solid Tumors
NCT05159700 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE1
-
A Phase 1, Dose-escalation Study of [225Ac]-FPI-2068 in Adult Patients With Advanced Solid Tumours
NCT06147037 ·Status: RECRUITING ·Phase: PHASE1
-
A Study to Assess the Safety and Pharmacokinetics of MOXR0916 and Atezolizumab (Also Known as MPDL3280A or Anti-PD-L1) in Participants With Locally Advanced or Metastatic Solid Tumors
NCT02410512 ·Status: COMPLETED ·Phase: PHASE1
-
A Study of PARG Inhibitor ETX-19477 in Patients With Advanced Solid Malignancies
NCT06395519 ·Status: RECRUITING ·Phase: PHASE1/PHASE2
-
A Study of AMG 337 in Subjects With Advanced Solid Tumors
NCT01253707 ·Status: COMPLETED ·Phase: PHASE1
-
A Study to Assess Safety and Pharmacokinetics of MOXR0916 in Participants With Locally Advanced or Metastatic Solid Tumors
NCT02219724 ·Status: COMPLETED ·Phase: PHASE1
-
A Phase 1/2a Study of 23ME-00610 in Patients With Advanced Solid Malignancies
NCT05199272 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE1/PHASE2
-
A Study to Investigate ANS014004 in Participants With Locally Advanced or Metastatic Solid Tumors
NCT06307795 ·Status: RECRUITING ·Phase: PHASE1
-
L-778,123 in Treating Patients With Recurrent or Refractory Solid Tumors
NCT00003430 ·Status: COMPLETED ·Phase: PHASE1
-
A Phase 1 Study of OMP-305B83 in Subjects With Solid Tumors
NCT02298387 ·Status: COMPLETED ·Phase: PHASE1
-
A Phase I Study of PM02734 in Subjects With Advanced Malignant Solid Tumors
NCT00404521 ·Status: TERMINATED ·Phase: PHASE1
-
A Phase 1 Clinical Study of AZD4635 in Patients With Advanced Solid Malignancies
NCT02740985 ·Status: COMPLETED ·Phase: PHASE1
-
Dose Escalation and Dose Expansion Study of MDX2001 in Patients With Advanced Solid Tumors
NCT06239194 ·Status: RECRUITING ·Phase: PHASE1/PHASE2
-
First-in-Human Study of the Safety, Tolerability, and Pharmacokinetic/Pharmacodynamic Profile of VX-984 in Combination With Chemotherapy
NCT02644278 ·Status: COMPLETED ·Phase: PHASE1
-
Ph. 1, Evaluation of Safety, Tolerability, PK, Anti-tumor Activity of STP707 IV in Subjects With Solid Tumors
NCT05037149 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE1
-
Phase I Study of WX-037 Alone and in Combination With WX-554 in Solid Tumours
NCT01859351 ·Status: TERMINATED ·Phase: PHASE1
-
Dose Escalation of RMC-5552 Monotherapy in Relapsed/Refractory Solid Tumors
NCT04774952 ·Status: COMPLETED ·Phase: PHASE1
-
Dose Escalation and Dose Expansion Study of MDX2004 in Participants With Advanced Tumors
NCT07110584 ·Status: RECRUITING ·Phase: PHASE1/PHASE2
-
A Phase 1 First-in-Human Study Evaluating AMG 900 in Advanced Solid Tumors
NCT00858377 ·Status: COMPLETED ·Phase: PHASE1
-
Dose Escalation and Expansion Study of BH3120 Alone or With Pembrolizuamb in Advanced or Metastatic Solid Tumors
NCT06234397 ·Status: RECRUITING ·Phase: PHASE1
-
Open-Label Study to Evaluate the Safety, Tolerability, PK, and Efficacy of INX-315 in Patients With Advanced Cancer
NCT05735080 ·Status: RECRUITING ·Phase: PHASE1/PHASE2
-
Study of SGR-3515 In Participants With Advanced Solid Tumors.
NCT06463340 ·Status: RECRUITING ·Phase: PHASE1
-
Study of PYX-106 in Solid Tumors
NCT05718557 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE1
-
Dose-Escalation and Dose-Expansion Study of BSI-082 Monotherapy and Combined Therapy in Patients With Advanced or Metastatic Solid Tumors
NCT07086768 ·Status: NOT_YET_RECRUITING ·Phase: PHASE1
-
First-in-Human Study of MS201408-0005A as Single Agent and in Combinations
NCT03306420 ·Status: TERMINATED ·Phase: PHASE1