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Detection and Significance of Heart Injury in ST Elevation Myocardial Infarction.

NCT02072850 · Status: ACTIVE_NOT_RECRUITING · Type: OBSERVATIONAL · Enrollment: 324

Last updated 2024-10-29

No results posted yet for this study

Summary

Heart imaging with magnetic resonance imaging (MRI) provides detailed insights into heart function and injury. The nature and significance of heart injury after a heart attack is incompletely understood. We propose a 'natural history' study of heart attack injury using contemporary MRI methods. In a large hospital in the West of Scotland, heart attack patients will be invited to have at least two MRI scans and also continue with life-long follow-up. The results from the MRI scans will be assessed with all of the other clinical information obtained at the time of the heart attack and during follow-up. The results of our study should provide new insights into heart attack injury and these results should help improve how heart attack patients should be treated.

Conditions

  • Acute ST-elevation Myocardial Infarction

Interventions

DEVICE

Coronary pressure wire

Guidewire-based coronary pressure- and temperature recordings (coronary thermodilution) with and without hyperaemia induced by intravenous administration of adenosine (140 ug/kg/min) in patients with acute ST-elevation myocardial infarction treated by emergency PCI.

OTHER

Magnetic resonance imaging of the heart

Cardiac magnetic resonance imaging (MRI) with gadolinium contrast imaging at baseline (\~ day 2) and 6 months (all participants) and in 30 subjects at 4 time-points (\< 12 hours, days 2, 7-10 and at 6 months).

Sponsors & Collaborators

  • Siemens Healthcare Diagnostics Inc

    collaborator INDUSTRY

  • British Heart Foundation

    collaborator OTHER

  • NHS National Waiting Times Centre Board

    lead OTHER

Principal Investigators

  • Colin Berry, MB ChB BSc PhD FRCP FACC · University of Glasgow

Eligibility

Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2011-05-31
Primary Completion
2012-11-30
Completion
2031-05-01

Countries

  • United Kingdom

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02072850 on ClinicalTrials.gov