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Predicting the Risk of Non-culprit Coronary Artery Disease After a Heart Attack

NCT05781087 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 90

Last updated 2024-09-25

No results posted yet for this study

Summary

Heart attacks caused by the complete blockage of a heart artery are treated by opening it with a stent. However, most people will also have 'non-culprit' narrowings found in their other arteries at this time.

Although in general people do better if these non-culprit narrowings are also treated with stents if they look severe, this process has problems. This is because narrowings that look severe may be stable and not cause any trouble. For these people a stent is a wasted procedure and unnecessary risk. On the other hand, narrowings that are currently left alone because they appear mild, may progress and cause a heart attack.

Participants who have had a heart attack will have a scan from inside the heart arteries during an angiogram (optical coherence tomography, OCT) and a magnetic resonance angiogram (MRA).

If the investigators can show that it is possible to accurately predict which non-culprit narrowings are going to progress and which are going to stabilise, medical professionals may be able to better target their treatments after a heart attack.

Conditions

Interventions

DIAGNOSTIC_TEST

Optical coherence tomography and pressure wire assessment

Non-culprit coronary arteries

DIAGNOSTIC_TEST

Cardiac magnetic resonance angiogram

1.5T

Sponsors & Collaborators

  • King's College London

    collaborator OTHER

  • King's College Hospital NHS Trust

    collaborator OTHER

  • Guy's and St Thomas' NHS Foundation Trust

    lead OTHER

Principal Investigators

  • Divaka Perera, MD · King's College London

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2023-04-25
Primary Completion
2025-10-31
Completion
2028-04-30

Countries

  • United Kingdom

Study Locations

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Entities

Diseases
Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05781087 on ClinicalTrials.gov