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The Use of Myocardial Deformation Imaging

NCT00476320 · Status: COMPLETED · Type: OBSERVATIONAL

Last updated 2007-05-22

No results posted yet for this study

Summary

Myocardial deformation imaging allows analysis of myocardial viability in ischemic left ventricular dysfunction. This study will evaluate the predictive value of myocardial deformation imaging for improvement in cardiac function after revascularization therapy in comparison to contrast-enhanced cardiac magnetic resonance imaging (ceMRI).

In 55 patients with ischemic left ventricular dysfunction, myocardial viability was assessed using pixel-tracking-derived myocardial deformation imaging and ceMRI to predict recovery of function at 9±2 months follow-up. For each left ventricular segment in a 16-segment model peak systolic radial strain will be determined from parasternal 2D echocardiographic views and the amount of late hyperenhancement (LE) and maximal thickness of myocardial tissue without LE using ceMRI. The hypothesis is that compared with segments showing functional improvement, those that failed to recover had lower radial strain and lower thickness without LE and higher LE.

Conditions

  • Myocardial Viability in Ischemic Left Ventricular Dysfunction
  • Prediction for Improvement in Cardiac Function After Revascularization Therapy

Interventions

PROCEDURE

Magnetic Resonance Imaging

PROCEDURE

Revascularization

PROCEDURE

Echocardiography with myocardial deformation imaging

Sponsors & Collaborators

  • RWTH Aachen University

    lead OTHER

Principal Investigators

  • Michael Becker, PhD, MD · RWTH Aachen University Hospital

  • Rainer Hoffmann, Professor · RWTH Aachen University Hospital

  • Malte Kelm, Professor · RWTH Aachen University Hospital

Eligibility

Min Age
18 Years
Max Age
80 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2004-08-31
Completion
2007-04-30

Countries

  • Germany

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00476320 on ClinicalTrials.gov