Multicenter Prospective Cohort Study on Current Treatments of Legg-Calvé-Perthes Disease

Summary

Legg-Calvé-Perthes disease is a childhood hip disorder which is common enough to be a significant public health problem (affects 1 in 740 boys between ages 0-14), but uncommon enough to have a sufficient number of patients from a single institution to perform a definitive prospective study comparing the results of current treatments. The present study will establish a database of prospectively identified patients with Legg-Calvé-Perthes (LCP) Disease and collect information regarding their presentation, treatment, and outcomes in the course of receiving currently available treatments.

This study seeks to compare the outcomes of current treatments in the management of different age groups (ages 1-6, 6-8, 8-11, \>11) of patients with Perthes disease at two- and five-year followup and at skeletal maturity. For each age group, two to three common treatment regimens currently used by practicing pediatric orthopaedic surgeons will be compared. The intervention a patient receives is determined through physician treatment expertise, and is not pre-determined by the study.

Conditions

• Legg Calve Perthes Disease

Interventions

PROCEDURE

Osteotomy + Long Term Non-Weight Bearing

Surgical procedure that improves femoral head containment, plus a post-operative protocol that requires patient to maintain non-weight bearing for 6 months.

PROCEDURE

Osteotomy + Short Term Non-Weight Bearing

Surgical procedure that improves femoral head containment, plus a post-operative protocol that allows early return to function after 6 weeks of non-weight bearing.

PROCEDURE

Nonoperative Observation

Group will not undergo any surgical or invasive procedures during course of treatment.

PROCEDURE

Multiple Epiphyseal Drilling

Multiple epiphyseal drilling is a procedure that creates small holes in the femoral head growth plate to increase blood flow into the femoral head.

Sponsors & Collaborators

• Alberta Children's Hospital

  collaborator OTHER

• Alfred I. duPont Hospital for Children

  collaborator OTHER

• Le Bonheur Children's Hospital

  collaborator OTHER

• Children's Hospital Colorado

  collaborator OTHER

• Children's Hospital Los Angeles

  collaborator OTHER

• Children's National Research Institute

  collaborator OTHER

• Children's Healthcare of Atlanta

  collaborator OTHER

• Children's Hospital of Philadelphia

  collaborator OTHER

• Children's Hospital Medical Center, Cincinnati

  collaborator OTHER

• Columbia University

  collaborator OTHER

• Connecticut Children's Medical Center

  collaborator OTHER

• Gillette Children's Specialty Healthcare

  collaborator OTHER

• Boston Children's Hospital

  collaborator OTHER

• Johns Hopkins University

  collaborator OTHER

• Kaiser Permanente

  collaborator OTHER

• Kasturba Medical College

  collaborator OTHER

• Montefiore Medical Center

  collaborator OTHER

• Nationwide Children's Hospital

  collaborator OTHER

• NYU Langone Health

  collaborator OTHER

• OrthoCarolina Research Institute, Inc.

  collaborator OTHER

• University of Sao Paulo General Hospital

  collaborator OTHER

• Seoul National University Childrens Hospital

  collaborator OTHER

• Shriners Hospitals for Children

  collaborator OTHER

• University Hospital Southampton NHS Foundation Trust

  collaborator OTHER

• Baylor College of Medicine

  collaborator OTHER

• Universitätsklinikum Hamburg-Eppendorf

  collaborator OTHER

• Ann & Robert H Lurie Children's Hospital of Chicago

  collaborator OTHER

• British Columbia Children's Hospital

  collaborator OTHER

• Children's of Alabama

  collaborator OTHER

• Hospital Infantil Universitario Niño Jesús, Madrid, Spain

  collaborator OTHER

• University of Oklahoma

  collaborator OTHER

• Oregon Health and Science University

  collaborator OTHER

• Rady Children's Hospital, San Diego

  collaborator OTHER

• San Jorge Children's Hospital (Puerto Rico)

  collaborator UNKNOWN

• University College Dublin

  collaborator OTHER

• Tianjin Children's Hospital

  collaborator OTHER

• University Hospital Schleswig-Holstein

  collaborator OTHER

• University of California, San Francisco

  collaborator OTHER

• University of Haifa

  collaborator OTHER

• Uppsala University

  collaborator OTHER

• Medical University of Lodz

  collaborator OTHER

• Oslo University Hospital

  collaborator OTHER

• Seattle Children's Hospital

  collaborator OTHER

• Mayo Clinic

  collaborator OTHER

• Texas Scottish Rite Hospital for Children

  lead OTHER

Principal Investigators

• Harry KW Kim, MD, MS · Texas Scottish Rite Hospital for Children

Eligibility

Min Age

1 Year

Max Age

18 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2012-08-31

Primary Completion

2032-09-30

Completion

2032-09-30

Countries

• United States
• Australia
• Brazil
• Canada
• China
• Germany
• India
• Ireland
• Norway
• Poland
• Puerto Rico
• Spain
• Sweden
• Switzerland
• United Kingdom

Study Locations