MedTrace Logo

Improving Infant Hydrocephalus Outcomes in Uganda

NCT03650101 · Status: ACTIVE_NOT_RECRUITING · Type: OBSERVATIONAL · Enrollment: 400

Last updated 2026-03-18

No results posted yet for this study

Summary

Neonatal postinfectious hydrocephalus (PIH) is a major public health problem in East Africa.The standard treatment has long been placement of a ventriculoperitoneal shunt (VPS) but these devices require life-long maintenance and nearly all fail multiple times. Endoscopic Third Ventriculostomy (ETV) with Choroid Plexus Cauterization (ETV/CPC) is an alternate treatment to give patients a shunt-free life. In this study, the investigators aim to optimize the metrics of evaluation as quantitative prognostic indicators of treatment response and long term outcomes.

Conditions

  • Hydrocephalus

Interventions

PROCEDURE

ETV/CPC

The Endoscopic Third Ventriculostomy/Choroid Plexus Cauterization (ETV/CPC) will comprise a standard frontal approach with flexible endoscopy.

Sponsors & Collaborators

  • The Hospital for Sick Children

    collaborator OTHER

  • CURE Children's Hospital, Uganda

    collaborator OTHER

  • Yale University

    collaborator OTHER

  • Boston Children's Hospital

    lead OTHER

Principal Investigators

  • Pei-Yi Lin, PhD · Boston Children's Hospital

Eligibility

Min Age
1 Day
Max Age
180 Days
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2021-05-05
Primary Completion
2025-05-15
Completion
2027-12-31

Countries

  • United States
  • Canada
  • Uganda

Study Locations

More Related Trials

Entities

Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03650101 on ClinicalTrials.gov