MedTrace Logo

fMRI and Ghlrein in Obesity and Binge Eating Disorder

NCT02038712 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 93

Last updated 2014-01-16

No results posted yet for this study

Summary

Binge Eating Disorder (BED) may be associated with he development of obesity. However, the pathogenesis of BED is currently unclear, thus making the development of treatment and prevention strategies for BED difficult. Differences in the mechanisms regulating food intake may go some way to reveal potential mechanisms for BED.The purpose of this study is to investigate the responses of key gut-derived hormones that are associated with the regulation of food intake and functional brain activity to food cues using fMRI in BED patients and weight matched controls.

Conditions

Interventions

DIETARY_SUPPLEMENT

Fed Condition

Subjects will consume a 600mL 600kcal liquid test meal

DIETARY_SUPPLEMENT

Fasted condition

Subjects will consume 600mL plain water.

PROCEDURE

Blood samples

Blood samples will be collected at -15, 0, 10, 30, 60, 90, 120 min

BEHAVIORAL

Subjective appetite ratings

Appetite ratings will be collected at -15, 0, 10, 30, 60, 90, 120 min.

PROCEDURE

fMRI scan

Blood Oxygen Dependent (BOLD) signal response to pictures and words of food and non-food items will be measured using functional magnetic resonance imaging (fMRI).

Sponsors & Collaborators

  • Columbia University

    collaborator OTHER

  • New York Obesity and Nutrition Research Center

    lead OTHER

Principal Investigators

  • Allan Geliebter, PhD · New York Obesity Nutrition Research Center

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Max Age
65 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2006-06-30
Primary Completion
2008-12-31
Completion
2013-09-30

More Related Trials

Entities

Diseases
Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02038712 on ClinicalTrials.gov