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Precursors of Binge Eating Disorder in a Clinical Sample of Adolescents With Obesity

NCT06387719 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 102

Last updated 2024-04-29

No results posted yet for this study

Summary

BACKGROUND: Binge eating disorder (BED) is the worldwide most-prevalent eating disorder. It is associated with psychiatric comorbidities and obesity, a high impact in life functioning, and high morbidity and mortality. First symptoms appear frequently in youths, who most commonly present incomplete (subthreshold) criteria for BED (precursor forms, PREC-BED). While some subjects will evolve from PREC-BED to BED, there is no gold standard to identify the clinical evolution. Information from prior studies suggest early alterations in reward and inhibitory brain circuits in PREC-BED may predict increased vulnerability or resilience to develop BED. Tools based on MRI brain connectivity analyses (MRI-BC), built on robust and interpretable connectivity whole-brain models, have proven successful in diagnostic classification and predicting certain clinical outcomes. OBJECTIVES: To study MRI-BC diagnostic markers of PREC-BED and to explore prognosis at 1 year of follow-up in a sample of adolescents with obesity (12-17 years old). METHODS: A) Transversal analytical design: 3-group (n=34 per group) comparison of neuroimaging (MRI-BC), neurocognitive and clinical markers in adolescents with obesity and i) BED, ii) PREC-BED, iii) no BED nor PREC-BED (Healthy group, HC). B) Longitudinal analytical design, pilot, exploratory: adolescents with PREC-BED will be evaluated in clinical and neurocognitive variables at 1 year. Baseline brain neuroimaging variables (alone and in combination with clinical and neurocognitive variables) will be analyzed as predictors of clinical prognosis, including conversion to BED.

Conditions

  • Binge-Eating Disorder
  • Obesity
  • Eating Disorders
  • BED
  • Other Specified Feeding or Eating Disorder
  • Eating Disorder Nos
  • Emotion Regulation
  • Food Addiction

Interventions

DIAGNOSTIC_TEST

Magnetic resonance imaging

* Basic sequence for ethical consideration: evaluation of casual findings. * Structural MRI. * Functional MRI (fMRI) in the Resting-state * fMRI- task based. Presented in a computer screen on a magnetically compatible googles.

Sponsors & Collaborators

  • Instituto de Salud Carlos III

    collaborator OTHER_GOV

  • Fundació Sant Joan de Déu

    lead OTHER

Principal Investigators

  • Esther Via, PhD · Hospital Sant Joan de Deu

Eligibility

Min Age
12 Years
Max Age
16 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2023-07-21
Primary Completion
2025-03-31
Completion
2026-05-31

Countries

  • Spain

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06387719 on ClinicalTrials.gov