Can Brisk Walking Combined With Ingestion of a Lipid-lowering Drug Improve Fat Metabolism in Muscle?

Summary

Briefly, participants will be assessed for their eligibility for the study using an oral glucose tolerance test, which involves drinking a sugary drink followed by a series of small blood samples. If eligible, participants will be asked to take part in a fitness test and then two trials which will involve walking on a treadmill at a steady pace. Before and after the exercise a small piece of muscle will be taken from their thigh under local anaesthesia, as well as several small blood samples. Muscle muscle samples will be assessed for lipid metabolites.

Conditions

• Pre Diabetes

Interventions

DIAGNOSTIC_TEST

Body Composition

Participants undergo a 5 minute body scan to determine their body composition.

DIAGNOSTIC_TEST

Maximal aerobic fitness test

Participants will complete a walking fitness text until exhaustion to determine maximal aerobic capacity.

DIAGNOSTIC_TEST

Oral glucose tolerance test

Participants will undergo an OGTT to determine insulin sensitivity.

OTHER

Muscle biopsy

Participants will give a small muscle sample pre-, immediately post and 3 hours post- the exercise trial to be assessed for lipid metabolites.

OTHER

Blood samples

Participants will give 16 blood samples, to be assessed for fatty acids in the blood.

Sponsors & Collaborators

• Diabetes UK

  collaborator OTHER

• Liverpool University Hospitals NHS Foundation Trust

  collaborator OTHER_GOV

• Royal Liverpool University Hospital

  collaborator OTHER_GOV

• Liverpool John Moores University

  lead OTHER

Principal Investigators

• Jennifer S Barrett, PhD · Liverpool John Moores University, L3 3AF

Study Design

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

NONE

Model

CROSSOVER

Eligibility

Min Age

25 Years

Max Age

55 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2019-10-01

Primary Completion

2024-07-31

Completion

2024-12-31

Countries

• United Kingdom

Study Locations