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Biliary Excretion of Conjugated Bile Acids in Humans Measured by 11C-cholylsarcosine PET/CT

NCT01879735 · Status: COMPLETED · Phase: PHASE1 · Type: INTERVENTIONAL · Enrollment: 22

Last updated 2015-02-23

Study results available
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Summary

We wish to develop a protocol for PET/CT examination of humans using the bile acid tracer 11C-cholylsarcosine. This is done by a series of PET/CT examinations of healthy humans and patients with cholestatic disorders.

Conditions

  • Cholestasis
  • Primary Sclerosing Cholangitis
  • Primary Biliary Cirrhosis

Interventions

DRUG

11C-CSar

PET/CT recording with bile acid tracer 11C-cholylsarcosine used to evaluate the transport of bile acids.

DRUG

ICG

Infusion of indocyanine green prior and during the PET/CT scanning with the bile tracer 11C-CSar.

Sponsors & Collaborators

  • University of Aarhus

    lead OTHER

Principal Investigators

  • Susanne Keiding, M.D. D.Sc. · Aarhus University Hospital

Study Design

Allocation
NON_RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2013-06-30
Primary Completion
2014-09-30
Completion
2014-09-30

Countries

  • Denmark

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01879735 on ClinicalTrials.gov