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Effect of Bile Acids on the Secretion of Satiation Peptides in Humans

NCT01674946 · Status: COMPLETED · Phase: PHASE1 · Type: INTERVENTIONAL · Enrollment: 12

Last updated 2012-08-29

No results posted yet for this study

Summary

The purpose of this study is do determine the functional significance of the G protein-coupled receptor TGR5 in the secretion of GI satiation peptides by using natural bile acids and oleanolic acid (triterpenoid compound of plant origin) as TGR5 agonists.

Conditions

  • Echolocation

Interventions

OTHER

saline

intraduodenal perfusion

OTHER

bile acid (CDCA, chenodeoxycholic acid)

intraduodenal perfusion

OTHER

oleanolic acid

intraduodenal perfusion

DIETARY_SUPPLEMENT

oleic acid

intraduodenal perfusion

Sponsors & Collaborators

  • University Hospital, Basel, Switzerland

    lead OTHER

Principal Investigators

  • Christoph Beglinger, MD · University Hospital Basel, Phase 1 Research Unit, Basel Switzerland

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
QUADRUPLE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Max Age
40 Years
Sex
MALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2011-09-30
Primary Completion
2011-12-31
Completion
2012-05-31

Countries

  • Switzerland

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01674946 on ClinicalTrials.gov