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Expression of BCRP in Icteric Patients

NCT00295360 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 40

Last updated 2006-02-23

No results posted yet for this study

Summary

The expression of transporters involved in bile acid homeostasis is differentially regulated during obstructive cholestasis. Bile acids are also substrates of the drug efflux transporter breast cancer resistance protein (BCRP) that is highly expressed in the human intestine. Therefore we intend to analyze whether intestinal BCRP expression could be altered during cholestasis.

Conditions

  • Icterus

Interventions

BEHAVIORAL

no intervention, pathophysiological study

Sponsors & Collaborators

  • University Hospital, Basel, Switzerland

    lead OTHER

Principal Investigators

  • Jürgen Drewe, MD, MSc · Department of Clinical Pharmacology, University Basel

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2003-06-30
Completion
2004-08-31

Countries

  • Switzerland

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00295360 on ClinicalTrials.gov