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Study of Bile Acids in Patients With Peroxisomal Disorders

NCT00004442 · Status: TERMINATED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 25

Last updated 2015-03-25

No results posted yet for this study

Summary

OBJECTIVES: I. Determine the effectiveness of oral bile acid therapy with cholic acid, chenodeoxycholic acid, and ursodeoxycholic acid in patients with peroxisomal disorders involving impaired primary bile acid synthesis.

II. Determine whether suppression of synthesis of atypical bile acids and enrichment of bile acid pool with this regimen is effective in treating this patient population and improving quality of life.

Conditions

  • Infantile Refsum's Disease
  • Zellweger Syndrome
  • Bifunctional Enzyme Deficiency
  • Adrenoleukodystrophy

Interventions

DRUG

chenodeoxycholic acid

DRUG

cholic acid

DRUG

ursodiol

Sponsors & Collaborators

  • Children's Hospital Medical Center, Cincinnati

    collaborator OTHER

  • University of Cincinnati

    lead OTHER

Principal Investigators

  • Kenneth Setchell · Children's Hospital Medical Center, Cincinnati

Study Design

Purpose
TREATMENT

Eligibility

Max Age
5 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Completion
1999-04-30

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00004442 on ClinicalTrials.gov