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Cigarette Smoking and Oral Microbiota

NCT01862809 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 50

Last updated 2020-06-30

No results posted yet for this study

Summary

Background:

\- Normal bacteria and other tiny organisms (the microbiota) live in the mouth and nose. They contribute to human health in many ways, including digesting food and balancing hormones. Testing samples from the mouth can show how microbiotas are related to health and disease. However, the microbiota in a person's mouth differs depending on the methods of collection and the part of the mouth that is tested. Understanding what can change the microbiota (including mouth sites, and what a person eats or smokes) will give more information on how to study oral microbiota and smoking-related cancers and other diseases.

Objectives:

* To see how smoking affects the microbiotas in mouth and nose.
* To determine which collection method for mouth specimens should be used for studying microbiota.

Eligibility:

* Individuals at least 18 years of age who have been using tobacco products regularly for at least 5 years.
* Individuals at least 18 years of age who have never smoked.

Design:

* Participants will be screened with a physical exam and medical history.
* Participants will have a dental exam. They will provide a saliva sample. The dentist will take swabs from the inside of the mouth, including the tongue, tonsils, gums, and teeth. The inside of the nose will also be swabbed.
* Participants will also fill out a questionnaire. It will ask about their history of smoking and consumption of alcohol, tea, and coffee. It will also ask about current medications, including antibiotics.

Conditions

Sponsors & Collaborators

  • National Cancer Institute (NCI)

    lead NIH

Principal Investigators

  • Neil E Caporaso, M.D. · National Cancer Institute (NCI)

Eligibility

Min Age
25 Years
Max Age
80 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2013-05-23
Primary Completion
2014-12-05
Completion
2020-06-26

Countries

  • United States

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01862809 on ClinicalTrials.gov