Bovine Milk Oligosaccharide Study

Summary

The purpose of this study is to elucidate tolerability and effectiveness in consumption of the complex indigestible sugars from dairy products called bovine milk oligosaccharides (BMO) to enrich intestinal microflora toward beneficial populations.

Conditions

• Healthy

Interventions

DIETARY_SUPPLEMENT

Bovine Milk Oligosaccharide

The BMO powder will be isolated from whey streams by Hilmar Ingredients (Hilmar, California 95324). Hilmar Ingredients employs the same membrane filtration, and centrifugation processes used to purify whey protein in their commercial practice to extract and purify BMO from whey permeate. Furthermore, the same sterilization processes used on the equipment to purify whey products will be used to purify BMO. This method uses a novel high-throughput food-grade isolation protocol that leads to purification of specific BMOs with bifidogenic activity as prebiotic oligosaccharides that mimic the activities observed for Human Milk Oligosaccharides (HMO). This strategy of developing methods for their large scale fractionation allows us to obtain a final product that mimics the naturally beneficial oligosaccharides present in human milk.

DIETARY_SUPPLEMENT

Placebo Glucose Polymer

Sponsors & Collaborators

• Dairy Research Institute

  collaborator OTHER

• University of California, Davis

  lead OTHER

Principal Investigators

• Daniela Barile, PhD · University of California, Davis

• Jennifer Smilowitz, PhD · University of California, Davis

• J. Bruce German, PhD · University of California, Davis

• Carolyn Slupsky, PhD · University of California, Davis

• Angela M Zivkovic, PhD · University of California, Davis

• David A Mills, PhD · University of California, Davis

Study Design

Allocation

NON_RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Model

CROSSOVER

Eligibility

Min Age

18 Years

Max Age

40 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2012-08-01

Primary Completion

2012-11-16

Completion

2021-01-22

Countries

• United States

Study Locations