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The Etiology and Progression of Brain Tumors

NCT01811524 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 2000

Last updated 2013-03-19

No results posted yet for this study

Summary

The main goal of the study is to present a framework, which integrates DNA, RNA and tissue data to identify and prioritize genetic events that represent clinically relevant new therapeutic targets and prognostic biomarkers for different kinds of brain tumors. The investigators study the regulation of neoplastic cell growth by oncogenes, tumor-suppressor and other cancer related genes using modern molecular genetic methods, such as chromogenic-in-situ hybridization, comparative genomic hybridization (CGH), array-CGH, cDNA microarray etc. In these studies the investigators utilize disease-specific tissue microarrays (TMA) which the investigators have constructed since 1999. Until now up to 3000 different brain tumours have been sampled to our TMA:s. These permit high-volume simultaneous analysis of molecular targets at the DNA, mRNA and protein levels. Research group has also focused its interest on the neoplastic development of gliomas, particularly on their hereditary and environmental factors.

Conditions

Sponsors & Collaborators

  • Tampere University

    collaborator OTHER

  • Tampere University Hospital

    lead OTHER

Principal Investigators

  • Hannu K Haapasalo, MD · Fimlab Laboratories, Tampere University Hospital, Tampere, Finland

Eligibility

Min Age
1 Month
Max Age
85 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
1983-09-30
Primary Completion
2009-12-31
Completion
2012-03-31

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01811524 on ClinicalTrials.gov