Servier agreed to acquire Day One for $2.5B, gaining an approved childhood brain tumor drug and pipeline assets. SCRI and MSD launched a collaboration to expand community oncology trial access, while Recursion took full ownership of REC-102 as Nvidia and Novo exited.
St. Jude Children’s Research Hospital experts are creating evidence-informed consensus guidelines covering brain tumor diagnosis, pharmacogenomics, survivorship care, and rare blood disorders. Their work helps clinicians translate the latest data into improved diagnosis, treatment, and follow-up care globally.
The blood-brain barrier continues to block most treatments for glioblastoma and central nervous system diseases, with only 0.01% of biologic drugs reaching the brain. New intellectual property coverage and synthetic methods aim to address delivery challenges.
Researchers have developed a remote-controlled CAR T-cell therapy that can be switched off on demand using venetoclax, while new engineering strategies aim to overcome barriers in treating glioblastoma and other solid tumors.
| NCT ID | Title | Status | Phase |
|---|---|---|---|
| NCT07769099 |
Musical Training: Promoting Brain Function in Children Who Have Survived Brain Tumours |
NOT_YET_RECRUITING | NA |
| NCT07710131 |
Neurocognitive Assessment CNSL and LGG |
NOT_YET_RECRUITING | NA |
| NCT07680439 |
Illuminate: A Clinical Study Evaluating CAR T Immune Cell Therapy (BCB-276) for Patients With Diffuse Intrinsic Pontine Glioma (DIPG). |
RECRUITING | PHASE2 |
| NCT07675070 |
Safety and Effectiveness Evaluation of Temozolomide (Amitzo, NanoAlvand) in Patients With Grade III and IV Glioma Tumors |
RECRUITING | |
| NCT07635329 |
Home-based Vision Rehabilitation Guided by Brain Imaging |
RECRUITING | NA |
| NCT07520370 |
Effect of Perioperative Ulinastatin on Postoperative Stroke in Patients With Brain Tumor |
NOT_YET_RECRUITING | NA |
| NCT07470606 |
Memantine +/- Raloxifene for Cognitive Preservation After Radiation Therapy to the Brain |
NOT_YET_RECRUITING | PHASE2 |
| NCT07418775 |
Tumor Genomics, Individual Risk Factors, and External Drivers of Health on Health Outcomes for Patients With Meningioma |
RECRUITING | |
| NCT07417085 |
MICRO-BRAIN 2024: Study on Pediatric Brain Tumors |
RECRUITING | NA |
| NCT07390539 |
B7-H3.CD28Z.CART in CNS Neoplasms |
NOT_YET_RECRUITING | PHASE1 |
