The blood-brain barrier continues to block most treatments for glioblastoma and central nervous system diseases, with only 0.01% of biologic drugs reaching the brain. New intellectual property coverage and synthetic methods aim to address delivery challenges.
Researchers have developed a remote-controlled CAR T-cell therapy that can be switched off on demand using venetoclax, while new engineering strategies aim to overcome barriers in treating glioblastoma and other solid tumors.
| NCT ID | Title | Status | Phase |
|---|---|---|---|
| NCT07520370 |
Effect of Perioperative Ulinastatin on Postoperative Stroke in Patients With Brain Tumor |
NOT_YET_RECRUITING | NA |
| NCT07470606 |
Memantine +/- Raloxifene for Cognitive Preservation After Radiation Therapy to the Brain |
NOT_YET_RECRUITING | PHASE2 |
| NCT07418775 |
Tumor Genomics, Individual Risk Factors, and External Drivers of Health on Health Outcomes for Patients With Meningioma |
RECRUITING | |
| NCT07417085 |
MICRO-BRAIN 2024: Study on Pediatric Brain Tumors |
RECRUITING | NA |
| NCT07390539 |
B7-H3.CD28Z.CART in CNS Neoplasms |
NOT_YET_RECRUITING | PHASE1 |
| NCT07381959 |
Biomarkers of Brain Injury in Children With Brain Tumors |
RECRUITING | |
| NCT07323966 |
Feasibility of Mask-Free Radiotherapy for Brain Tumor Patients |
RECRUITING | NA |
| NCT07254845 |
A PROSPECTIVE, SINGLE-CENTERED, ASSESSOR-BLINDED STUDY TO EVALUATE THE CLINICAL EFFICACY OF THE PROPOSED CELL/TISSUE HISTOPATHOLOGY PROCESSOR CCELL (CONFOCAL FLUORESCENCE ENDOMICROSCOPY) FOR INTRAOPERATIVE DIAGNOSIS IN BRAIN TUMORS |
NOT_YET_RECRUITING | PHASE1 |
| NCT07226466 |
Evaluating Biomarkers of Cognitive Dysfunction in Patients With Cancer |
NOT_YET_RECRUITING | |
| NCT07224503 |
C-SMART vs BE Well for Patients With Brain Tumors |
RECRUITING | NA |
