Glioma is a malignant tumor arising from glial cells in the brain or spinal cord. It includes multiple subtypes such as astrocytoma, glioblastoma, oligodendroglioma, and ependymoma, with heterogeneous biology and prognosis. Gliomas account for a substantial share of central nervous system tumors.
UVA Health found gliomas may be more receptive to focused ultrasound drug delivery. Related research covers miRNA therapy, low-intensity focused ultrasound, and 3D organoid drug testing.
A new "expand and pull" treatment strategy combines long-acting interleukin-7 and oncolytic virus therapy to boost T cell response in glioblastoma. In mouse models, the combination improved cytotoxic T cell function and led to long-term tumor-free survival.
Cancer care is being transformed by targeted therapy, immunotherapy, personalized medicine, and emerging mRNA-based universal cancer vaccines. Advances in immunotherapeutics and cellular therapies are improving survival rates, while an off-the-shelf mRNA vaccine from the University of Florida is already in human trials.
Telix Pharmaceuticals has submitted regulatory applications for TLX101-Px, a brain cancer imaging agent, to both the European Medicines Agency and the U.S. Food and Drug Administration, seeking approval for glioma diagnosis and treatment monitoring.
Telix Pharmaceuticals submitted a marketing authorization application in Europe for TLX101-Px, a glioma imaging agent, on February 18, 2026. The filing covers major European markets and a U.S. NDA submission will follow.
| NCT ID | Title | Status | Phase |
|---|---|---|---|
| NCT07781852 |
Evaluation of the Distribution of 64Cu/68Ga Labeled CM500 in Healthy Volunteers and Patients With Cancer |
NOT_YET_RECRUITING | EARLY_PHASE1 |
| NCT07778979 |
Multiparametric Metabolic and Hypoxic PET/MRI Imaging Substudy in Gliomas |
NOT_YET_RECRUITING | EARLY_PHASE1 |
| NCT07754734 |
STUPP Regimen With or Without Lenvatinib for Newly Diagnosed Glioblastoma With MGMT Promoter Methylation |
NOT_YET_RECRUITING | PHASE2 |
| NCT07750457 |
Proton vs. Photon Radiotherapy for Patients With WHO Grade 2-3 Glioma |
RECRUITING | NA |
| NCT07725640 |
Feasibility Assessment of a Medical Device for Tumour Cell Retention and Radiotherapy Sensitization in Patients With Suspected High-grade Glioma |
NOT_YET_RECRUITING | NA |
| NCT07717827 |
Connectome-guided Onco-functional Resection With Tractography-Extended Neuronavigation in Brain Tumor Surgery |
RECRUITING | |
| NCT07703761 |
AI-driven Processing and Analysis of Glioma Imaging Data |
RECRUITING | |
| NCT07703605 |
AI-Assisted MRI Molecular Subtyping in Pediatric Brain Tumors |
NOT_YET_RECRUITING | |
| NCT07703436 |
Safety and Efficacy Study of Safusidenib in Participants With IDH1-Mutant Glioma Who Discontinued Vorasidenib Treatment Due to Progressive Disease |
NOT_YET_RECRUITING | PHASE2 |
| NCT07699172 |
EEG-Guided Cognitive Function Preservation in Patients With Brain Tumors |
NOT_YET_RECRUITING | NA |
