Risk Factors for Adult-Onset Brain Tumors

Summary

Study Objective:

Brain tumors are poorly understood. The purpose of this research is to examine whether factors in lifestyle play a role in brain tumor development. The study will also investigate the contribution of inherited susceptibility to the risk of brain cancer. By gaining a better understanding of these influences, the investigators hope to learn how to prevent brain tumors in future generations, and to develop more effective strategies for treatment.

Study Protocol:

This is a case-control investigation. Persons affected with a brain tumor are compared to unaffected persons on previous medical history, diet and other factors. Those enrolled in the study will participate in an interview on general background, diet, medical history and lifestyle, and will provide a sample of DNA, clippings of your toenails, and a tap water sample from your home. All procedures are performed in the clinic or through the mail.

'Cases': Cases eligible for the study are persons with a recent diagnosis of a primary brain tumor (glioma or meningioma), at least 18 years of age.

'Controls': Controls in the study are non-family members of patients, similar in age and of the same gender. Suitable controls include in-laws, friends, neighbors and co-workers.

Conditions

• Brain Neoplasm, Primary
• Brain Neoplasms, Malignant
• Brain Neoplasms, Benign

Sponsors & Collaborators

• H. Lee Moffitt Cancer Center and Research Institute

  collaborator OTHER

• Kentuckiana Cancer Institute

  collaborator OTHER

• Emory University

  collaborator OTHER

• University of Alabama at Birmingham

  collaborator OTHER

• Vanderbilt University Medical Center

  lead OTHER

Principal Investigators

• Kathleen M. Egan, DSc · H. Lee Moffitt Cancer Center

• Reid C. Thompson, MD · Vanderbilt University Medical Center

• Renato V. LaRocca, MD · Kentuckiana Cancer Center

• Jeffrey Olson, MD · Emory University

• Burt Nabors, MD · University of Alabama at Birmingham

Eligibility

Min Age

18 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2003-10-31

Primary Completion

2015-01-31

Completion

2015-01-31

Countries

• United States

Study Locations