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Targeting Specific Brain Networks to Treat Specific Symptoms in Depression

NCT05523817 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 80

Last updated 2025-09-29

No results posted yet for this study

Summary

Repetitive transcranial magnetic stimulation (rTMS) is a way of non-invasively stimulating specific brain networks and is an established treatment for Major Depressive Disorder (MDD). This proposal will reveal network mechanisms of the therapeutic effects of rTMS by investigating how stimulating each network specifically changes network connectivity and behavior. This will be done in a highly individualized manner in depressed and healthy patients, leading to more effective and more individualized treatments for depression.

Conditions

Interventions

DEVICE

Intermittent Theta Burst Stimulation (iTBS)

iTBS is a form of non-invasive brain stimulation used to treat depression. It works on the principles of electromagnetic induction.

Sponsors & Collaborators

  • Massachusetts General Hospital

    lead OTHER

  • National Institute of Mental Health (NIMH)

    collaborator NIH

Study Design

Allocation
NON_RANDOMIZED
Purpose
OTHER
Masking
DOUBLE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Max Age
65 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2024-03-12
Primary Completion
2027-12-31
Completion
2028-12-31
FDA Device
Yes

Countries

  • United States

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05523817 on ClinicalTrials.gov