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Functional Brain Imaging Study of Response to Repetitive TMS (rTMS) Treatment of Major Depression

NCT01768052 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 40

Last updated 2015-05-04

No results posted yet for this study

Summary

The investigators plan to use optical brain imaging technology to observe patients with current major depression before, during, and after repetitive Transcranial Magnetic Stimulation (rTMS) clinical treatment. Clinical treatment involves 20-30 rTMS sessions over the course of 4-6 weeks.

Our primary hypotheses are as follows:

1. Primary Hypothesis: In patients with a positive response to rTMS, the investigators will observe an increase in the strength of connectivity as measured by fMRI among brain regions in the cognitive control network after 4 weeks of treatment.
2. Secondary Hypothesis: Brain activation measured by functional Near-Infrared Spectroscopy(fNIRS) in the dorso-lateral prefrontal cortex (DLPFC) during rTMS will increase as the number of treatments increase. Detection of this increase in brain activity at the beginning of the treatment help researchers and physicians assess treatment response.

Conditions

Interventions

DEVICE

functional Near Infrared Spectroscopy

fNIRS monitoring during rTMS treatment sessions.

Sponsors & Collaborators

  • National Alliance for Research on Schizophrenia and Depression

    collaborator OTHER

  • Mclean Hospital

    lead OTHER

Principal Investigators

  • Yunjie Tong, PhD · Mclean Hospital

  • Blaise Frederick, Ph.D. · Mclean Hospital

  • Oscar Morales, M.D. · McLean Hospital, Transcranial Magnetic Stimulation (TMS) Service

Eligibility

Min Age
21 Years
Max Age
45 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2013-06-30
Primary Completion
2016-01-31
Completion
2016-01-31

Countries

  • United States

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01768052 on ClinicalTrials.gov