Regular Use Effect of Inhaled Ipratropium Bromide on Airway Responsiveness to Methacholine in Well-controlled Asthma
NCT04167280 · Status: COMPLETED · Phase: PHASE4 · Type: INTERVENTIONAL · Enrollment: 12
Last updated 2020-03-26
Summary
Study is looking at the development of tolerance to methacholine following regular use of ipratropium bromide in mild asthmatics.
Conditions
Interventions
- DRUG
-
Ipratropium Metered Dose Inhaler
MDI to deliver 20mcg per puff ipratropium bromide
- DRUG
-
placebo metered dose inhaler
matched MDI to deliver inactive drug
Sponsors & Collaborators
-
University of Saskatchewan
lead OTHER
Principal Investigators
-
Don Cockcroft, MD · University of Saskatchewan
Study Design
- Allocation
- RANDOMIZED
- Purpose
- TREATMENT
- Masking
- TRIPLE
- Model
- CROSSOVER
Eligibility
- Min Age
- 18 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2019-11-05
- Primary Completion
- 2020-03-13
- Completion
- 2020-03-13
Countries
- Canada
Study Locations
More Related Trials
-
Study to Investigate the Effect of Inhaled Tiotropium Bromide on Neurokinin-A Induced Bronchoconstriction in Patients With Mild-to-moderate Asthma
NCT00557700 ·Status: COMPLETED ·Phase: PHASE2
-
A Study to Assess the Efficacy of Inhaled Corticosteroid (ICS) Therapy in Moderate-Severe Bronchial Asthma
NCT00411567 ·Status: COMPLETED ·Phase: PHASE1/PHASE2
-
A Study to Evaluate the Sensitivity and Specificity of Inhaled Methacholine in Bronchial Provocation Test
NCT05634473 ·Status: UNKNOWN ·Phase: NA
-
A Study to Assess and Compare Safety and Tolerability of 3 Months Treatment With Salbutamol Administered Via MDI Containing Propellant HFA-152a or HFA-134a in Participants ≥ 18 Years of Age With Asthma
NCT06261957 ·Status: COMPLETED ·Phase: PHASE3
-
BE Study of Albuterol Sulfate Inhalation Aerosol 90 mcg Per Actuation in Patients With Stable Mild Asthma
NCT06154304 ·Status: COMPLETED ·Phase: PHASE3
-
Bronchodilating and Bronchoprotective Effects of Deep Inspirations
NCT01659476 ·Status: COMPLETED ·Phase: NA
-
Comparing the Efficacy of Bricanyl M2 and Bricanyl M3 at 0.5 and 1.5 mg Dose Levels, to Allow for a Switch From Bricanyl Turbuhaler M2 to Bricanyl Turbuhaler M3
NCT02322788 ·Status: COMPLETED ·Phase: PHASE3
-
Bronchoprotection of Salbutamol in Asthma and Chronic Obstructive Pulmonary Disease
NCT00440245 ·Status: COMPLETED ·Phase: PHASE4
-
A Study to Evaluate the Effect of of Albuterol Sulfate Inhalation Aerosol, eq 90 mcg Base (Sun Pharmaceuticals Industries Limited)
NCT03528577 ·Status: COMPLETED ·Phase: PHASE3
-
A Comparison of Levalbuterol Plus Ipratropium With Levalbuterol Alone in the Treatment of Acute Asthma Exacerbation
NCT00583778 ·Status: COMPLETED ·Phase: NA
-
Pharmacodynamic Bioequivalence of Metered Dose Inhalers of Albuterol Sulfate in Patients With Stable Mild Asthma
NCT02624505 ·Status: COMPLETED ·Phase: PHASE3
-
Effect of a LAMA and a uLABA on the Methacholine Dose-response Curve
NCT02953041 ·Status: COMPLETED ·Phase: PHASE4
-
Therapeutic Relevance of Abnormal Airway Morphology in Asthma
NCT06970080 ·Status: RECRUITING ·Phase: PHASE4
-
Examination of the Bronchoprotective Effect of Endothelin Receptor Blockade in Asthma
NCT01617746 ·Status: UNKNOWN ·Phase: PHASE2
-
Defining and Treating Depression-related Asthma
NCT04617015 ·Status: COMPLETED ·Phase: EARLY_PHASE1
-
Evaluate the Therapeutic Effect of Inhaled Corticosteroid in Asthmatic Children
NCT03487809 ·Status: RECRUITING
-
Salbutamol Tolerance Onset
NCT01338311 ·Status: COMPLETED ·Phase: PHASE4
-
Study of Daily Dosing With Levalbuterol, Racemic Albuterol, and Placebo in Pediatric Subjects With Asthma
NCT00073814 ·Status: COMPLETED ·Phase: PHASE3
-
Airway Response to Repeat Allergen Challenge and the Effect of Ibuprofen in Mild Atopic Asthma
NCT02327234 ·Status: COMPLETED ·Phase: NA
-
Study to Assess the Efficacy of Ipratropium Bromide Associated With High Dose Salbutamol by Repeated Nebulisation Versus Repeat Nebulisation of Salbutamol Alone, in Acute Asthmatic Attacks in Young Children
NCT02235428 ·Status: TERMINATED ·Phase: PHASE4
-
Modification of Asthma With Soy Isoflavone
NCT00741208 ·Status: COMPLETED ·Phase: NA
-
Safety, Tolerability, and Pharmacokinetics of PA9159 Inhalation Aerosol in Healthy Adult Subjects
NCT06916273 ·Status: COMPLETED ·Phase: PHASE1
-
Pharmacodynamic Equivalence of the Test and Reference Metered Dose Inhalers (MDIs) Containing Albuterol Sulfate in Adult Patients With Stable Mild Asthma
NCT04912596 ·Status: RECRUITING ·Phase: NA
-
Spirometry and Methacholine Challenge Test in Asthmatic Children Age 3-6years
NCT00550758 ·Status: TERMINATED ·Phase: NA
-
Inhaled Steroid Treatment as Regular Therapy in Early Asthma
NCT00641914 ·Status: COMPLETED ·Phase: PHASE4