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Different Surgical Modalities in the Treatment of Periodontitis

NCT01642641 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 36

Last updated 2025-03-10

No results posted yet for this study

Summary

The purpose of the present study is to determine: 1) the efficacy of 2 periodontal surgical procedures, the conservative simplified papilla preservation technique and the more resective open flap debridement with osseous recontouring, in the treatment of chronic periodontitis in terms of clinical, radiographic, microbiological, immunological and PROMs, comparing them to non-surgical subgingival debridement and 2) if possible, determine the surgical procedure which leads to pocket elimination or to the lowest number of residual pockets.

Conditions

  • Chronic Periodontitis

Interventions

PROCEDURE

Non-surgical Subgingival Debridement (SD)

SD is a conservative non-surgical procedure aimed at reducing dental plaque and calculus from the tooth root usually under local anaesthesia.

PROCEDURE

Simplified Papilla Preservation Flap

The simplified papilla preservation flap is a novel conservative surgical procedure aimed at the preservation of the tissues between the teeth. It has been shown to significantly reduce pocket depth and has faster re-vascularisation of the flap, when compared with other procedures.

PROCEDURE

Resective Periodontal Flap with Osseous Recontouring (RPFO)

RPFO is a surgical procedure that involves the resection of soft and hard tissue to obtain optimum tissue architecture and pocket reduction or elimination.

Sponsors & Collaborators

  • Queen Mary University of London

    lead OTHER

Principal Investigators

  • Nikolaos Donos, DDS, MS, PhD · Barts & The London School of Medicine & Dentistry, QMUL

  • Nikolaos Mardas, DDS, MS, PhD · Barts & The London School of Medicine & Dentistry, QMUL

  • Natalie M Leow, BDS, MDSc · UCL Eastman Dental Institute

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Model
PARALLEL

Eligibility

Min Age
30 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2016-10-30
Primary Completion
2023-12-31
Completion
2023-12-31

Countries

  • United Kingdom

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01642641 on ClinicalTrials.gov