Preimplantation Genetic Screening (PGS) in Advanced Female Age and Male Severe Factor

Summary

Preimplantation Genetic Screening (PGS) is used for the selection of chromosomally normal embryos before the transfer in IVF treatments in many cases. There is great debate in the scientific community as to whether this is an efficient practice in patients of different prognosis.

This prospective and randomized study seeks to study the results of chromosomal diagnosis using the new Comparative Genomic hybridization (CGH) arrays technique by practicing Preimplantation Genetic Screening (PGS) in day three biopsy on one arm of the study and not on the other arm in order to compare the results. The investigators will study the ongoing pregnancy rate of each oocyte retrieval and the ongoing implantation rate with Day 5 embryos (blastocysts) in IVF/ intracytoplasmic sperm injection (ICSI) treatments of embryos from two different groups of patients: Advanced Age Female Patients (38 - 41 years of age) and Male severe factor (≥2 million spermatozoids/ml.).

Conditions

• Embryo Aneuploidies
• Implantation Rates
• Infertility

Interventions

GENETIC

PGS

Preimplantation Genetic Screening of the embryos and posterior transfer of ongoing Day 5 blastocysts.

GENETIC

PGS

Preimplantation Genetic Screening of the embryos and posterior transfer of ongoing Day 5 blastocysts.

OTHER

Prolonged culture

The embryos will be in prolonged culture and on going embryos transferred on Day 5 .

OTHER

Prolonged culture

Prolonged culture of the embryos and posterior transfer of ongoing Day 5 blastocysts.

Sponsors & Collaborators

• Igenomix

  lead INDUSTRY

Principal Investigators

• Carlos Simon, MDPhD · Director

• Carmen Rubio, PhD · Igenomix

Study Design

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

NONE

Model

PARALLEL

Eligibility

Min Age

18 Years

Max Age

60 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2012-02-29

Primary Completion

2014-09-30

Completion

2015-02-28

Countries

• Spain

Study Locations