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Embryos With Preimplantation Genetic Testing for Aneuploidies (PGT-A) Inconclusive Result: Clinical Implications

NCT04734769 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 600

Last updated 2021-02-02

No results posted yet for this study

Summary

One of the most remarkable improvements in trophoectoderm cells biopsy is the robustness of diagnosis as result of analyzing multiple cells. However, there is a proportion of embryos that lack of diagnosis due to amplification failure or inconclusive results ranging between 0,4% and 6%. Information about embryo repeated biopsy after an inconclusive result in a first biopsy is very scarce. No specific conclusions can be drawn, due to the limited information currently available concerning reproductive outcomes for patients who had embryo transfer after a second biopsy, due to a first one having an inconclusive result. Investigators purpose a multicenter retrospective observational study with the aim to evaluate the reproductive potential of re-biopsied blastocyst with inconclusive results on preimplantation genetic screening for aneuploidy (PGT-A) using the implantation rate (IR) and ongoing pregnancy rate (OPR) as principal variables.

Conditions

  • Embryo Disorder

Interventions

OTHER

Collect retrospectively clinical data on reproductive outcomes

Collect retrospectively clinical data on reproductive outcomes

Sponsors & Collaborators

  • Instituto Valenciano de Infertilidad, IVI VALENCIA

    collaborator OTHER

  • Juno Therapeutics, Inc., a Bristol-Myers Squibb Company

    collaborator INDUSTRY

  • IVI Vigo

    lead OTHER

Principal Investigators

  • Elkin Muñoz · IVI Vigo

Eligibility

Min Age
18 Years
Max Age
45 Years
Sex
FEMALE
Healthy Volunteers
No

Timeline & Regulatory

Start
2021-02-20
Primary Completion
2021-02-21
Completion
2022-11-25

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04734769 on ClinicalTrials.gov