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Inherited Reproductive Disorders

NCT01500447 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 850

Last updated 2026-05-12

No results posted yet for this study

Summary

Background:

\- During puberty, children begin to develop into adults. Problems with the hormones released during puberty can affect the reproductive system. Some people have low hormone levels that severely delay or prevent puberty. Others start puberty abnormally early. Other people may have a normal puberty but develop reproductive disorders later in life. Researchers want to study people with reproductive disorders to learn more about how these disorders may be inherited.

Objectives:

\- To learn how reproductive system disorders may be inherited.

Eligibility:

* People with one of the following problems:
* Abnormally early puberty
* Abnormally late or no puberty
* Normal puberty with hormonal problems that develop later in life
* People who have not yet had puberty but have symptoms that indicate low hormone levels.

Design:

* Participants will provide a blood sample for testing. They will complete a questionnaire about their symptoms. They will also have a scratch-and-sniff test to study any problems with their ability to smell.
* Participant medical records will be reviewed. Participants will also provide a family medical history.
* Family members of those in the study may be invited to participate.
* Treatment will not be provided as part of this study.

Conditions

Sponsors & Collaborators

Principal Investigators

  • Natalie D Shaw, M.D. · National Institute of Environmental Health Sciences (NIEHS)

Eligibility

Min Age
6 Weeks
Max Age
120 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2012-04-25

Countries

  • United States

Study Locations

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Entities

Diseases
Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01500447 on ClinicalTrials.gov