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Next Generation to Identify Genetic Causes of Disease in Patients Participating in NICHD Clinical Protocols

NCT01375543 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 128

Last updated 2020-01-06

No results posted yet for this study

Summary

Background:

\- The purpose of this study is to identify changes in genes that cause human diseases. We would like to obtain some of you or your child s DNA and test for changes in genes that may contribute to a disease in you or your family.

Objective:

-To allow for exomic or genomic sequencing of NICHD patients or family members in order to identify changes in genes that cause or contribute to a specific disease.

Eligibility:

* Children who are enrolled in an NICHD clinical study where the condition being studied may have a genetic cause.
* Family members of a child who is eligible for this study.

Design:

* Children and family members will supply DNA samples. If the samples are already available, no further DNA will be needed.
* If DNA is not available, samples of either blood or skin will be taken.
* We will use these samples with new DNA sequencing technology that looks at all the human genes we know about. This is known as exome and genome sequencing.

Conditions

  • Genetic Predisposition

Sponsors & Collaborators

  • Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)

    lead NIH

Principal Investigators

  • An N Dang Do, M.D. · Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)

Eligibility

Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2011-06-16
Primary Completion
2018-11-27
Completion
2019-12-31

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01375543 on ClinicalTrials.gov