Genetic Susceptibility to Radiation-Induced Skin Reactions in Racial/Ethnic Groups of Patients With Breast Cancer

Summary

RATIONALE: Radiation therapy uses high-energy x rays to kill tumor cells. Radiation therapy may cause skin reactions when patients are exposed to high-energy x rays. Studying the genetic pattern of patients before and after radiation therapy may help doctors prevent toxicity and plan the best treatment.

PURPOSE: This clinical trial studies genetic susceptibility to radiation-induced skin reactions in racial/ethnic groups of patients with breast cancer.

Conditions

• Breast Cancer
• Cognitive Ability, General
• Fatigue
• Pain
• Psychosocial Deprivation
• Radiation Toxicity
• Skin Abnormalities

Interventions

GENETIC

DNA analysis

Genetic

GENETIC

gene expression analysis

Genetic

OTHER

enzyme-linked immunosorbent assay

Genetic

OTHER

flow cytometry

Genetic

OTHER

laboratory biomarker analysis

Genetic

OTHER

questionnaire administration

Genetic

PROCEDURE

adjuvant therapy

Genetic

PROCEDURE

assessment of therapy complications

Genetic

PROCEDURE

quality-of-life assessment

Genetic

RADIATION

3-dimensional conformal radiation therapy

Genetic

RADIATION

breast irradiation

Genetic

RADIATION

external beam radiation therapy

Genetic

RADIATION

hypofractionated radiation therapy

Genetic

RADIATION

intensity-modulated radiation therapy

Genetic

RADIATION

whole breast irradiation

Genetic

Sponsors & Collaborators

• National Cancer Institute (NCI)

  collaborator NIH

• Wake Forest University Health Sciences

  lead OTHER

Principal Investigators

• James J. Urbanic, MD · Wake Forest University Health Sciences

Eligibility

Min Age

18 Years

Sex

FEMALE

Healthy Volunteers

No

Timeline & Regulatory

Start

2011-09-20

Primary Completion

2014-08-26

Completion

2014-08-26

Countries

• United States

Study Locations