MRI and Gene Expression in Diagnosing Patients With Ductal Breast Cancer In Situ

Summary

This clinical trial studies magnetic resonance imaging (MRI) and gene expression in diagnosing patients with abnormal cells in the breast duct that have not spread outside the duct. MRI uses radio waves and a powerful magnet linked to a computer to create detailed pictures of areas inside the body. MRI may help find and diagnose patients with breast cancer. It may also help doctors predict a patient's response to treatment and help plan the best treatment. Genetic studies may help doctors predict the outcome of treatment and the risk for disease recurrence. Performing MRI with genetic studies may help determine the best treatment for patients with breast cancer in situ.

Conditions

• Ductal Breast Carcinoma In Situ

Interventions

PROCEDURE

Magnetic Resonance Imaging

Undergo MRI

PROCEDURE

Therapeutic Conventional Surgery

Undergo mastectomy

PROCEDURE

Therapeutic Surgical Procedure

Undergo wide local excision

RADIATION

Radiation Therapy

Undergo radiation therapy

DRUG

Endocrine Therapy

Undergo endocrine therapy

OTHER

Quality-of-Life Assessment

Ancillary studies

OTHER

Laboratory Biomarker Analysis

Correlative studies

OTHER

Cytology Specimen Collection Procedure

Correlative studies

Sponsors & Collaborators

• National Cancer Institute (NCI)

  collaborator NIH

• Eastern Cooperative Oncology Group

  collaborator NETWORK

• ECOG-ACRIN Cancer Research Group

  lead NETWORK

Principal Investigators

• Constance Lehman · ECOG-ACRIN Cancer Research Group

Study Design

Allocation

NON_RANDOMIZED

Purpose

DIAGNOSTIC

Masking

NONE

Model

CROSSOVER

Eligibility

Min Age

18 Years

Sex

FEMALE

Healthy Volunteers

No

Timeline & Regulatory

Start

2015-03-25

Primary Completion

2027-11-30

Completion

2027-11-30

Countries

• United States

Study Locations