Study of Radiation Exposure and Bilateral Breast Cancer

Summary

This study is being done to find out what factors may be related to the risk of getting a second breast cancer among women who already have breast cancer in one breast. It will look at how genes, treatment for breast cancer; including radiation therapy, and the effects of different lifestyle activities, may affect the risk of breast cancer. It will use different processes to find genes that might increase the risk of breast cancer. The results of this study may help to develop better ways to detect, treat and prevent breast cancer. This study will compare women who have breast cancer in both breasts to women who have breast cancer in only one breast.

Conditions

• Breast Cancer

Interventions

OTHER

questionaire, blood or saliva sample

Take part in an approximately 45 minute telephone interview, with questions about detailed treatment (chemotherapy, hormonal therapy, radiation therapy (RT)) for all study participants. Their medical records will be reviewed to get further details about treatment of their breast cancer. They donate either a 35 ml blood sample (about 3 tablespoons) or a saliva sample. Blood Sample: if patient consents to give a blood sample, following the interview, they will be contacted by our staff phlebotomist (a person trained to draw blood). A scheduled appointment to draw a blood sample from you at your home. At the time of the blood draw, the phlebotomist will collect approximately 2 and 1/3 tablespoons of blood. Saliva Sample: if they choose not to give a blood sample, but consent to give a saliva sample instead, a saliva kit will be sent to there home. Once they provide the sample in the kit, they will be asked to mail back the sample in the pre-labeled kit that was sent to them.

Sponsors & Collaborators

• Translational Genomics Research Institute

  collaborator OTHER

• University of Southern California

  collaborator OTHER

• University of Virginia

  collaborator OTHER

• Lund University

  collaborator OTHER

• Ontario Cancer Registry (OCR) and Mount Sinai Hospital- Toronto (MSHT)

  collaborator UNKNOWN

• Northern California Cancer Center

  collaborator OTHER

• Fred Hutchinson Cancer Center

  collaborator OTHER

• University of Iowa

  collaborator OTHER

• Danish Cancer Society

  collaborator OTHER

• Beckman Research Institute

  collaborator OTHER

• City of Hope National Medical Center

  collaborator OTHER

• M.D. Anderson Cancer Center

  collaborator OTHER

• Vanderbilt University School of Medicine

  collaborator OTHER

• NYU Langone Health

  collaborator OTHER

• University of Chicago

  collaborator OTHER

• University of California, Irvine

  collaborator OTHER

• Stanford University

  collaborator OTHER

• Memorial Sloan Kettering Cancer Center

  lead OTHER

Principal Investigators

• Jonine Bernstein, PhD · Memorial Sloan Kettering Cancer Center

Eligibility

Min Age

18 Years

Max Age

54 Years

Sex

FEMALE

Healthy Volunteers

No

Timeline & Regulatory

Start

2009-05-31

Primary Completion

2026-05-31

Completion

2026-05-31

Countries

• United States
• Canada
• Denmark

Study Locations