Vaccine denial and weakened public health measures risk increasing chronic illness, as historical data shows post-infectious conditions follow major outbreaks. Long COVID affects 10-20% of those infected, while historical pandemics led to conditions like encephalitis lethargica with near 50% mortality.
The treatment landscape for multiple myeloma is evolving rapidly with T-cell engaging therapies like bispecific antibodies and CAR T-cell treatments shifting care toward a chronic condition with potential treatment breaks. This evolution is creating new side effect management challenges and complicating clinical trial design as sponsors grapple with selecting comparator arms and adapting to a rapidly shifting standard of care.
Two new studies reveal long COVID's lasting biological and mental health effects. A mouse study found coronavirus triggers prolonged lung and brain damage unlike influenza, while a population study linked long COVID to significantly higher depression and anxiety risks up to three years post-infection.
Acromegaly patients face persistent symptoms including fatigue, joint pain, headaches, and brain fog despite biochemical control. Treatment burden and financial barriers remain significant, particularly in sub-Saharan Africa where diagnostic tools and therapies are often inaccessible.
Telix said Part 1 of the ProstACT Global Phase 3 study met its primary objectives for TLX591-Tx in mCRPC. The company reported acceptable safety, no new safety signals and progression plans for Part 2.
GLP-1 drugs used for type 2 diabetes and obesity are seeing rising demand for weight loss as safety concerns also draw attention. A 2025 WHO guideline said long-term safety data remains limited.
A 12-week supervised remote exercise program for patients with metastatic renal cell carcinoma undergoing immunotherapy showed significant improvements in health-related quality of life, fatigue, and symptom burden in a case series of 19 patients.
The FDA has approved Optune Pax, a Tumor Treating Fields device, for use with chemotherapy in locally advanced pancreatic cancer. The approval is based on phase 3 trial data showing improved overall survival and pain progression outcomes. This marks the first new treatment approach for this patient population in approximately 30 years.
Atezolizumab combined with chemotherapy shows significant benefits in dMMR/MSI-H colorectal cancer. In stage III disease, the ATOMIC trial demonstrated improved 3-year DFS (86.3% vs 76.2%) with atezolizumab plus mFOLFOX6. For metastatic disease, the COMMIT trial showed superior PFS (24.5 vs 5.3 months) with atezolizumab, bevacizumab, and FOLFOX versus atezolizumab monotherapy.
The FDA has expanded approval of GSK's Arexvy RSV vaccine to include adults aged 18 to 49 years at increased risk for lower respiratory tract disease, based on phase 3b trial data showing noninferior immune response.
| NCT ID | Title | Status | Phase |
|---|---|---|---|
| NCT07606170 |
The Impact of Fatigue on Quality of Life and Activities of Daily Living in Pediatric Oncology Patients |
ENROLLING_BY_INVITATION | |
| NCT07604519 |
Multi-Ingredient Supplementation in Professional Football Players |
NOT_YET_RECRUITING | NA |
| NCT07603180 |
ROBO-PAWS: Robot-Dog-Assisted Walking |
NOT_YET_RECRUITING | NA |
| NCT07602933 |
Photobiomodulation Effects on Fatigue and Muscle Damage Induced by NMES |
NOT_YET_RECRUITING | NA |
| NCT07575607 |
Reflexology Versus Progressive Muscle Relaxation for Fatigue in Hemodialysis Patients |
NOT_YET_RECRUITING | NA |
| NCT07572578 |
Radicle Women's HealthTM: A Study Assessing the Impact of Health and Wellness Products on Fatigue and Related Health Outcomes Among Women Experiencing Menopausal Symptoms |
NOT_YET_RECRUITING | NA |
| NCT07572305 |
Effects of Virtual Reality After Liver Transplantation |
COMPLETED | NA |
| NCT07564830 |
Association Between Sarcopenia, Fatigue and Orthostatic Intolerance in Geriatric Patients: A Case Control Study |
NOT_YET_RECRUITING | |
| NCT07562074 |
Transcranial Magnetic Stimulation for Depression in Multiple Sclerosis |
NOT_YET_RECRUITING | PHASE1 |
| NCT07551817 |
The Effect of Art-Based Intervention on Fatigue, Anxiety, Perception of Nurse Presence, and Quality of Life in Patients With Hematological Cancers |
NOT_YET_RECRUITING | NA |
