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The Median Effective Dose (ED50) of Paracetamol and Morphine : A Study of Interaction Study

NCT01366313 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 90

Last updated 2012-12-10

No results posted yet for this study

Summary

The aim of our study is to define the median effective analgesic doses (ED50) of paracetamol, morphine, and their combination and determination the nature of their interaction administered IV for postoperative pain after moderate painful surgery using up-and-down and isobolographic methods.

Conditions

  • Postoperative Pain

Interventions

DRUG

Paracetamol

initial doses was 1.5g, with dose adjustment intervals of 0.5g . with maximum dose 2.5 g as an only starting dose / 24 h

DRUG

Morphine

Initial of morphine was 5mg, with dose adjustment intervals 1 mg .

DRUG

Paracetamol- Morphine

The initial doses of paracetamol and morphine were 1.5g and 3mg, respectively in the paracetamol-morphine combination group with dose adjustment intervals of 0.25g for paracetamol and 0.5mg for morphine.

Sponsors & Collaborators

  • Procare Riaya Hospital

    lead OTHER

Principal Investigators

  • AHED ZEIDAN, MD · Procare Riaya Hospital

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2007-09-30
Primary Completion
2011-03-31
Completion
2011-03-31

Countries

  • Saudi Arabia

Study Locations

More Related Trials

Entities

Drugs

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01366313 on ClinicalTrials.gov