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Analgesic Effect of Intrathecal Morphine Combined With Low Dose Local Anesthetics on Postoperative Analgesia After Liver Resection

NCT05208801 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 90

Last updated 2022-01-26

No results posted yet for this study

Summary

Efficient postoperative pain control plays a vital part in the management of patients after surgery. In particular, major surgeries including hepatectomy cause intense postoperative pain that may result in cardiovascular or respiratory complications post-surgery. One of the current methods of postoperative pain control after hepatectomy involves a multimodal approach including intrathecal morphine injection immediately prior to surgery. Because morphine alone is inadequate for immediate postoperative pain control due to a late peak effect time of 6 hours, current literature advocates a combination injection including bupivacaine. However, higher doses of bupivacaine may inadvertently cause motor block or hemodynamic side effects. The aim of this study was to compare the effectiveness and side effects of intrathecal morphine combined with low dose bupivacaine against intrathecal morphine alone and no intrathecal injection.

Conditions

  • Patients Receiving Hepatectomy Under General Anesthesia

Interventions

DRUG

Percutaneous injection

A sham procedure of 2 ml of 1% lidocaine injected percutaneously using the initial 25G needle for local anesthetics

DRUG

Morphine

Intrathecal injection of morphine 400mcg

DRUG

Morphine+Bupivacaine

Intrathecal injection of 5mg of 0.5% bupivacaine chloride

Sponsors & Collaborators

  • Yonsei University

    lead OTHER

Principal Investigators

  • Bon-Nye Koo · Department of Anesthesiology and Pain Medicine, Yonsei University College of Medicine

Study Design

Allocation
NON_RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Model
FACTORIAL

Eligibility

Min Age
19 Years
Sex
MALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2018-11-19
Primary Completion
2020-04-18
Completion
2020-04-18

Countries

  • South Korea

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05208801 on ClinicalTrials.gov