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Non-opioid Analgesic Combination With Morphine for Postoperative Analgesia.

NCT01882530 · Status: TERMINATED · Phase: PHASE4 · Type: INTERVENTIONAL · Enrollment: 223

Last updated 2018-02-06

No results posted yet for this study

Summary

The combination of different analgesic drugs and/or analgesia techniques is part of the standard management of postoperative analgesia. The analysis of the literature reveals a lack of comparison of the associations of non-opioid analgesic (NOA) with morphine for postoperative analgesia.

The objectives of this study are :

* comparing the morphine sparing effect of different combination of 3 NOA (paracetamol, nefopam, ketoprofen) for postoperative analgesia.
* determining whether the morphine-sparing effect is associated with or without a reduction in the incidence of morphine side effects.
* evaluating the effects of NOA on postoperative hyperalgesia.

Conditions

  • Post Operative Analgesia

Interventions

DRUG

Paracetamol

DRUG

Nefopam

DRUG

Ketoprofen

DRUG

Morphine

Sponsors & Collaborators

  • Rennes University Hospital

    lead OTHER

Principal Investigators

  • ERIC BELLISSANT · Rennes University Hospital

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Model
FACTORIAL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2013-07-23
Primary Completion
2016-01-16
Completion
2016-01-16

Countries

  • France

Study Locations

More Related Trials

Entities

Drugs

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01882530 on ClinicalTrials.gov