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The Predictive Capacity of Peripheral Muscle Function on Quality of Life Impairment at 1 Year in Subjects With Obesity

NCT05479396 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 90

Last updated 2024-07-01

No results posted yet for this study

Summary

The assessment of health status and physical function is fundamental in patients with obesity, as they play an important role among the various factors influencing quality of life in this population. Several studies have shown an association between high BMI values and a significant deterioration in quality of life, especially in women. Excess body fat in obese patients appears to be responsible for impaired muscle function. This causal link is probably linked to dysfunctions in adipose tissue, leading to a decrease in the expression of proteins responsible for muscle contraction. The recent literature highlights an alteration in quality of life, particularly in obese and elderly subjects, for which changes in muscle function are partly responsible.

Changes in muscle function can be assessed by simple, rapid and non-invasive tools. These changes in the obese patient could be predictive of reduced quality of life. To our knowledge, no study has evaluated the predictive capacity of muscle alteration assessed by ultrasound on the medium-term quality of life of obese patients.

The main objective of this study is to evaluate the predictive capacity of structural alteration of the quadriceps on the decrease in quality of life at 1 year in patients with obesity.

The secondary objectives are to assess the association between :

* Grip strength and quality of life at 1 year;
* Quadriceps muscle strength and quality of life at 1 year;
* Ultrasound measurements of the quadriceps and quality of life at 1 year;
* Ultrasound measurements of the quadriceps and autonomy at 1 year;
* Grip strength and autonomy at 1 year.

This is a prospective, monocenter, observationnal and cohort study.

All outpatients for nutrition assessment will be included.

Conditions

Sponsors & Collaborators

  • Hopital Forcilles

    lead OTHER

Principal Investigators

  • Sophie VIDAL-JESSEL, MD · Hopital Forcilles

  • Andreia GOMES LOPES, MSc · Hopital Forcilles

  • Aymeric Le Neindre · Hopital Forcilles

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2022-04-22
Primary Completion
2023-07-10
Completion
2024-02-05

Countries

  • France

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05479396 on ClinicalTrials.gov