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Functional Implications of TNF

NCT00729131 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 10

Last updated 2014-09-29

No results posted yet for this study

Summary

The research plan proposes to develop translational studies in humans that will identify host susceptibility factors that confer vulnerability to the prototypal air pollutant, ozone. Ozone is a ubiquitous urban air pollutant and associated with increased emergency room visits, and co-associates with other air pollutants, to increase mortality in high risk groups (cardio-pulmonary disease) of the population.The results will have significant impact upon and aid in understanding mechanisms of pro-oxidant lung injury, airway hyperresponsiveness, and adverse health effects, that occur during and following exposure to inhalable airborne irritants.

Conditions

  • Bronchitis

Interventions

DRUG

Etanercept inhibition of ozone-induced airway hyper-responsiveness.

Single dosage of etanercept(50 mg, subcutaneous) given 2 days prior to a laboratory ozone exposure.

Sponsors & Collaborators

  • National Institute of Environmental Health Sciences (NIEHS)

    lead NIH

Eligibility

Min Age
18 Years
Max Age
35 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2008-08-31
Primary Completion
2010-01-31
Completion
2012-02-29

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00729131 on ClinicalTrials.gov