MedTrace Logo

Smoker Extracellular Vesicles Influence on Human Bronchial Epithelial Cells

NCT03608293 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 20

Last updated 2018-07-31

No results posted yet for this study

Summary

Cigarette smoking is a habit that has spread all over the world and is a significant risk factor for many diseases including cardiovascular disease, chronic obstructive pulmonary disease(COPD),asthma and lung cancer.

Evaluation and understanding of tobacco health effects are of major interest worldwide and answer to important societal concerns.

Identification of new biomarkers of exposure to tobacco smoke potentially implicated in COPD or lung carcinogenesis would allow a better observation of tobacco exposed population, thanks to screening establishment at reversible stages of pathological processes.

In this study, we question whether cigarettes smoking alters miRNA profiles of extracellular vesicles (EVs) present in human broncho alveolar lavages (BALs), which could affect surrounding normal bronchial epithelial cells status.

Conditions

  • Smokers
  • Human Bronchial Epithelial Cells
  • Lung Pathogenesis
  • Biomarkers

Interventions

DIAGNOSTIC_TEST

Broncho Alveolar Lavages (BAL)

BEAS-2 B cells are exposed to EVs isolated from BAL of smokers and non-smokers.

Sponsors & Collaborators

  • Universite du Littoral Cote d'Opale

    collaborator OTHER

  • Lille Catholic University

    lead OTHER

Principal Investigators

  • Pierre Gosset, MD · GHICL

Study Design

Allocation
NON_RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2012-01-01
Primary Completion
2013-07-31
Completion
2013-12-31

More Related Trials

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03608293 on ClinicalTrials.gov