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Relationship of Urine Sodium Excretion to Central Blood Pressure and Aortic Pulse Wave Velocity

NCT01237717 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 200

Last updated 2013-01-23

No results posted yet for this study

Summary

One interesting area is the relationship of high salt intake and central aortic blood pressure. High salt intake is associated development of hypertension and cardiovascular mortality. Central aortic pressure is better correlated with cardiovascular events and mortality. With recent advances in technology, it is possible to measure central aortic pressure noninvasively and easily. Until now there is no study to evaluate the relationship of high salt intake and aortic blood pressure.

The purpose of the present study is to evaluate the relationship of high salt intake and aortic blood pressure and aortic stiffness.

Subjects with or without hypertension will be enrolled for investigation. Subjects with hypertension should be never treated with antihypertensive medications. Subjects with secondary hypertension, diabetes, heart failure, high grade kidney disease, ischemic heart disease, and major arrhythmia will be excluded.

Sodium intake is measured by 24 hour urinary sodium excretion, with the measurement of peripheral and central aortic blood pressure, and aortic pulse wave velocity.

Salt sensitive hypertension related single nucleotide polymorphism will be analyzed to define the relationship with high salt intake and aortic pressure and pulse wave velocity.

Conditions

Sponsors & Collaborators

  • The Korean Society of Cardiology

    collaborator OTHER

  • DongGuk University

    lead OTHER

Principal Investigators

  • Moo-Yong Rhee, Prof,MD, PhD · Cardiovascular Center, Dongguk University Ilsan Hospital

Eligibility

Min Age
35 Years
Max Age
65 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2010-05-31
Primary Completion
2011-12-31
Completion
2011-12-31

Countries

  • South Korea

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01237717 on ClinicalTrials.gov