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Assessing Cerebral Blood Flow Autoregulation During Surgery in the Head-up Position

NCT01225185 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 240

Last updated 2017-08-22

No results posted yet for this study

Summary

Neurological injury after elective shoulder surgery in the beach chair position is thought to result from cerebral hypoperfusion and should therefore be preventable by appropriate hemodynamic monitoring and management. This proposal will use a system to continuously monitor cerebral blood flow autoregulation to identify safe arterial blood pressure targets in patients in the beach chair position, compared with a control cohort having orthopedic surgery in the lateral decubitus supine position. Autoregulation data will be compared against a new, highly specific and sensitive serum biomarker of neurologic injury, glial fibrillary acid protein, and postoperative neurocognitive testing results.

Conditions

  • Shouldersurgery

Sponsors & Collaborators

  • National Heart, Lung, and Blood Institute (NHLBI)

    collaborator NIH

  • Anesthesia Patient Safety Foundation

    collaborator OTHER

  • Johns Hopkins University

    lead OTHER

Principal Investigators

  • Charles W Hogue, MD · The Johns Hopkins Medical Institutions

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2010-07-31
Primary Completion
2014-03-31
Completion
2015-04-30

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01225185 on ClinicalTrials.gov